XRPediatrics is a lab within the Center for Immersive Technology in Pediatrics, part of the department of Pediatrics at the Yale School of Medicine. XRPediatrics focuses on the use of extended reality (virtual, augmented, and mixed reality) and game technology in applications, interventions, and research with the goal of improving lives and reducing disparities among youth and their families. Our mission is to provide effective and safe XR applications for youth, with a particular focus on those at risk for experiencing health disparities associated with race/ethnicity, age, gender, sexual identity, socioeconomic status, and disability. We have over 15 years of experience developing, evaluating, and implementing XR and game-based interventions and clinical applications with youth.